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Aim and scope: Pharmacogenomics is among the most representative research areas in modern science. It studies the influence of genetic variations of individual genes to drug response. Given a genetic profile the aim is to be able to prescribe the most appropriate drug and dosage. Drugs will be designed by analyzing the proteins, enzymes and RNA molecules associated with genes related to the given disease. The main lectures of the School address the scope focusing on tumor angiogenesis, genomes and omic data, integrative systems biology, protein docking and chemoinformatics. A series of tutorial is also offered to illustrate basic preliminary concepts and complement the main lectures by providing snapshots of related areas. These range from web services, protein structures, microarray data analysis, metrics on molecules, systems pharmacology, sequencing analysis, to transcriptomic data analysis and epigenomics. From the enclosed bibliography it appears that the selected themes have received much attention in the scholarly literature ranging from Nature and Science to BMC Bioinformatics and Bioinformatics.
Speakers
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Pierre Baldi
From Genomes to Drug Leads: Integrative Systems Biology Approaches [abstract]
University of California, Irvine, USA
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Michael Levitt
Solving the Elusive Structure of Group II Chaperonin TRiC/CCT by Mass Spectrometry, Exhaustive Enumeration and Sentinel Correlation Analysis [abstract]
Stanford University, USA
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Lydia Kavraki
Geometry and robotics-inspired methods for the analysis of protein function and the design of new medicines [abstract]
Rice, Houston, Texas, USA
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Dave Ritchie
Protein Docking and 3D Ligand-Based Virtual Screening [abstract]
INRIA Nancy Grand-Est, France
Tutorials
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Alberto Apostolico
Compositional Sequence Analysis and Classification [abstract]
Georgia Tech, Atlanta, USA - University of Padova, Italy
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Filippo Utro
Ancestral Recombination Graph: Theory and Applications [abstract]
Computational Genomics, T. J. Watson Research Center, Yorktown Heights, NY USA
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Rosalba Giugno, Giuseppina Cantarella
Network analysis in systems pharmacology [abstract]
University of Catania, Italy
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Eric Jonasch
Molecular determinants of response and resistance to antiangiogenic therapy in renal cell carcinoma [abstract]
The University of Texas MD Anderson Cancer Center, Houston, TX, USA
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Michael Levitt
Introduction to Protein Three-Dimensional Structure and the Architecture of Drug Binding Sites [abstract]
Stanford University, USA
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Giosuè Lo Bosco
Machine Learning Methods for Epigenomic Analyis [abstract]
University of Palermo, Italy
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Peter Minary
Towards Computational Structural Epigenetics at DNA/RNA Levels [abstract]
Stanford University, USA
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Luca Pinello
Epigenetic plasticity: why DNA sequence matters [abstract]
Dana Faber Cancer Research Center and Harvard University, USA
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Chandra Verma
The Role of Flexibility in Protein-Protein Interactions and Therapeutic Design [abstract]
Bioinformatics Institute in Singapore
School Directors
- Prof. Alfredo Ferro (University of Catania)
- Prof. Raffaele Giancarlo (University of Palermo)
- Prof. Concettina Guerra (University of Padova and Georgia Tech.)
- Prof. Michael Levitt, (Stanford University)
- Prof. Renato Bernardini (co-director, University of Catania)
- Dr. Rosalba Giugno (co-director, University of Catania)
- Dr. Alfredo Pulvirenti (co-director, University of Catania)
