Aim and scope: The theme of the school, RNAs : structure,
function and therapy,
falls within the areas of Bioinformatics & Biomedicine, and
deals specifically with bioinformatics and biomedical aspects of
RNAs analysis. There are four lecture series, each of three
hours, a lecture series of one hour, and nine tutorials, each of
one hour. The lectures will cover fundamental aspects relating
to the study and the analysis of transcription and translation
mechanisms and their spatial-temporal regulation. Gene
regulatory factors that control the expression of genomic
information come in a variety of flavors, with transcription
factors and microRNAs representing the most numerous gene
regulatory factors in multicellular genomes.
Two series of lectures are devoted to RNA interference, with
special emphasis on mechanisms of post transcriptional
regulation by microRNAs in vivo with case studies from the brain
and the involvement of microRNAs in cancer, while the other two
are devoted to mathematical, physical and computational methods
needed to analyse RNAs.
The tutorials will cover the most recent advances in
computational methods for RNAs: sequences and structures.
Moreover, they will also highlight recent additional results on
protein-RNA interactions. Thus they nicely complement the main
lectures. As it is clear from the enclosed bibliography, the
selected themes have received much attention in the scholarly
literature that ranges from Nature to BMC Bioinformatics and
Bioinformatics. In its entirely the planned summer school will
allow young researchers interested in bioinformatics and
biomedicine to be exposed to cutting edge results in the
increasingly important area of RNAs analysis in biology.
List of Speakers
-
Carlo Croce
The involvement of microRNAs in cancer: from research to diagnosis and therapy
Department of Molecular Virology,
Immunology and Medical Genetics and Comprehensive Cancer Center
Ohio State University, Columbus, Ohio, USA
-
Oliver Hobert
Mechanisms of post-transcriptional regulation by microRNAs in vivo. Case studies from the brain [abstract]
HHMI Investigator
Columbia University Medical Center
Department of Biochemistry and Molecular Biophysics
New York, NY, USA
-
Debora Marks
Micro and siRNA transfections affect the function of endogenous microRNAs
Systems Biology Department, Harvard Medical School
Boston, MA, USA
-
Chris Sander
Pathways regulatory control using RNAi systematic perturbation
MSKCC - Computational Biology Center
New York, NY, USA
-
Peter Stadler
Inside the RNA analysis: sequences, structures and functions [abstract]
Institut für Informatik Universität Leipzig
Leipzig, Germany
Guest Speakers
-
Charles R. Cantor
Detecting specific RNAs in living cells [abstract]
Chief Scientific Officer/Director/Chairman of the Board, Divisional Sequenom, Incorporated
San Diego, CA, USA
-
Graziano Pesole
Gene complexity and Alternative Splicing
President of the Bioinformatics Italian Society (BITS)
Dipartimento di Biochimica e Biologia Molecolare University of Bari
Istituto Tecnologie Biomediche del C.N.R.
Italy
Tutorials
-
Doron Betel
Non coding RNAs [abstract]
MSKCC - Computational Biology Center
New York, NY, USA
-
Matteo Comin
RNA-protein interaction [abstract]
University of Padova, Padova, Italy
-
Raffaele Giancarlo
Alignment-free Classification and Comparison of Biological Sequences and Structures [abstract]
University of Palermo, Palermo, Italy
-
Christine Heitsch
Strings, Trees, and RNA Folding [abstract]
Georgia Institute of Technology, USA
-
Alessandro Laganà
Tools for miRNA genes and target prediction [abstract]
University of Catania, Italy
-
Debora Marks
Principles of microRNAs: genomics, biogenesis, mechanism, and function[abstract]
Systems Biology Department
Harvard Medical School
Boston, MA, USA
-
Alfredo Pulvirenti
Algorithms for RNA structure alignment [abstract]
University of Catania, Italy
-
Knut Reinert
SeqAn, A a generic C++ library for the analysis of biological sequences [abstract]
Freie Universität Berlin, Germany
School Directors
- Prof. Alfredo Ferro (University of Catania)
- Prof. Raffaele Giancarlo (University of Palermo)
- Prof. Concettina Guerra (University of Padova and Georgia Tech.)
- Prof. Michael Levitt, (Stanford University)
- Dr. Rosalba Giugno (co-director, University of Catania)
- Dr. Alfredo Pulvirenti (co-director, University of Catania)
