Protein-RNA interaction
Protein–RNA interactions are crucial for many cellular processes, such as gene
expression and regulation as well as protein synthesis. Understanding and predicting
such interactions at the atomic level are crucial for our ability to interfere with
malfunctioning processes in disease. Consequently, analysis of the protein–RNA
interactions and RNA binding sites has been a field of intensive research. In this
tutorial we will discuss the connections between the widely studied prediction of
protein-ligand binding sites and the recent analysis of protein-RNA interactions.
Current methodologies based on inter-atomic and geometrical properties will be
presented.
References:
Shulman-Peleg A, Shatsky M, Nussinov R, Wolfson HJ. Prediction of interacting single-stranded RNA bases by protein-binding patterns. J Mol Biol. 2008 May 30;379(2):299-316.
N Morozova, J Allers, Y Shamoo. ProteinRNA interactions: exploring binding patterns with a three-dimensional superposition analysis of high resolution structures by: Bioinformatics, Vol. 22, No. 22. (15 November 2006), pp. 2746-2752.