Elucidating the topology and logic of cellular pathways
A fundemantal problem in network biology is to infer the
signaling-regulatory pathways that underlie a process of interest.
This inference task starts with elucidating the topology of the pathway,
continues with assigning directions and influence signs to its
interactions and ends with a full logical model that describes its
workings. In this set of talks we will review methods for network
reconstruction, orientation, sign assignment and Boolean modeling.
We will demonstrate the applications of these methods to decipher
disease mechanisms and drug response pathways.