Roded Sharan, Tel Aviv University

A systems-level analysis of protein networks for disease elucidation
In recent years, there is a tremendous growth in large scale data on human proteins, their interactions, and their relations to diseases. These allow for the first time a systems-level analysis of the molecular basis of disease. In my talk I will describe several recent works in this direction, aiming to uncover novel disease proteins and their underlying pathways with implications to diagnosis and therapy.

Bibliography (partial as some papers are still in the making):

  1. Toward accurate reconstruction of functional protein networks. Yosef et al.
    Molecular Systems Biology, 5, #248, 2009

  2. Associating genes and protein complexes with disease. Vanunu et al. PLoS Computational Biology, 6, #e1000641, 2010.