Carlo Croce, Human cancer Genetics Program; Ohio State University

Causes and Consequences of miRNA Disregulation in Cancer
During the past several years it has become clear that alterations in the expression of microRNA genes contribute to the pathogenesis of most, perhaps all, human malignancies. These alterations can be caused by a variety of mechanisms, including deletions, amplifications or mutations involving microRNA loci, by epigenetic silencing or by dysregulation of transcription factors targeting specific microRNAs. Since malignant cells show dependence on the dysregulated expression of microRNA genes, which in turn control or are controlled by dysregulation of multiple protein coding oncogenes or tumor suppressor genes, these small RNAs provide important opportunities for development of future microRNA based therapies.

References

  1. Nana-Sinkam P and Croce CM. MicroRNAs in diagnosis and prognosis in cancer: what does the future hold?
    Pharmacogenomics. 11:667-669, 2010.

  2. Di Leva G and Croce CM. Roles of small RNAs in tumor formation.
    Trends Mol Med. 16:257-267, 2010.

  3. Iorio MV, Piovan C and Croce CM. Interplay between microRNAs and the epigenetic machinery: An intricate network. Biochim Biophys Acta. 2010 May 19.
    [Epub ahead of print].

  4. Garofalo M, Croce CM. MicroRNAs: master regulators as potential therapeutics in cancer. Annual Review Toxicology and Pharmacology.
    July, 2010 in press

  5. Tili E, Michaille J-J and Croce CM. miR-155: On the crosstalk between inflammation and cancer.
    Int Rev Immunol., 28:264-284, 2009.

  6. Iorio MV and Croce CM. MicroRNAs in cancer: small molecules with a huge impact.
    J Clin Onc., 27:5848-5856, 2009.