Roded Sharan, Tel Aviv University, Tel Aviv, Israel

Comparative Analysis of Protein Networks
Data on protein-protein interactions are increasing exponentially. To date, large scale protein interaction networks are available for human and most model species. The arising challenge is to organize these networks into models of cellular machinery. As in other biological domains, a comparative approach provides a powerful basis for addressing this challenge. This series of lectures will cover the on-going effort for analyzing protein-protein interaction networks across species to infer conserved protein modules and predict protein function and interaction.

The first of the lectures will discuss techniques for comparing two networks to identify significantly conserved subnetworks. The second will discuss the problem of querying a protein pathway/complex within a network of interest. The third will briefly survey techniques for integrating molecular networks of different types to obtain a comprehensive description of molecular process within the cell.

 

R. Sharan and T. Ideker. (2006). Modelling cellular machinery through biological network comparison. Nature Biotechnology 24:427-433.

R. Sharan et al. (2005). Conserved patterns of protein interaction in multiple species. Proc. National Academy of Sciences , USA 102 :1974-79. (protein network comparison).

B. Dost et al. (2007). QNet: a tool for querying protein interaction networks. Proc. RECOMB , pp. 1-15. (network querying).

K. Tan et al. (2007). Transcriptional regulation of protein complexes within and across species. Proc. National Academy of Sciences , USA 104 :1283-88. (network integration).